Firing Rate Information  Parameter Adaptation  Parameter Adaptation

  
Adapted Parameter Values

The following tables list the final adapted conductance parameters, after equations (ii)-(iv)--maximizing the information in the cell's
firing rate--were used to adjust the peak conductances, midpoint voltages, and slopes of the ``dendritic"  and
conductances over the course of $10.9 \; \text{(simulated) minutes.}$  Initial values  for the conductance parameters are listed in tables 1 and 2.

As described in the text, the model contains three  and three conductances, each characterized by five variables: a peak conductance  (here compared relative to the leak or membrane conductance ) and the midpoint  and slope  of the single activation and inactivation functions. These represent the thirty variables in the model that are subject to adaptation.
 

Uniform Distribution of Firing Rates

Table 3: Adapted parameters of the voltage-dependent $\text {Ca}^{2+}$ conductances for Figs. 2a and 2b. Constraint on the minimum and maximum firing rate imposed during adaptation, leading to a uniform (optimal) distribution of spike counts.

 

peak conductance	act. midpoint	act. slope	inact. midpoint	inact. slope
$\bar{g}_i/g_{\text{leak}}$	$V_{1/2}$ [mV]	$s$ [mV]	$V_{1/2}$ [mV]	$s$ [mV]
1.668	-10.8	5.9	6.7	-7.0
1.597	-6.3	5.8	16.5	-7.7
0.767	8.7	9.4	30.1	-9.7

  

   

 

peak conductance	act. midpoint	act. slope	inact. midpoint	inact. slope
$\bar{g}_i/g_{\text{leak}}$	$V_{1/2}$ [mV]	$s$ [mV]	$V_{1/2}$ [mV]	$s$ [mV]
1.450	-60.5	8.6	-35.6	-9.4
2.618	-49.9	5.7	-28,8	-5.1
0.047	-30.2	15.0	-12.0	-11.1

  

 
 
Exponential Distribution of Firing Rates  

Table 5: Adapted parameters of the voltage-dependent $\text {Ca}^{2+}$ conductances for Fig. 2c. Constraint on average firing rate imposed during adaptation, leading to a Boltzmann (exponentially decaying) distribution of spike counts.

 

peak conductance	act. midpoint	act. slope	inact. midpoint	inact. slope
$\bar{g}_i/g_{\text{leak}}$	$V_{1/2}$ [mV]	$s$ [mV]	$V_{1/2}$ [mV]	$s$ [mV]
2.789	-12.6	9.0	24.5	-5.6
4.320	12.2	3.4	29.9	-4.4
2.427	1.9	5.6	33.2	-6.8

  

 
   

Table 6: Adapted parameters of the voltage-dependent $\text {K}^{+}$ conductances for Fig. 2c.

 

peak conductance	act. midpoint	act. slope	inact. midpoint	inact. slope
$\bar{g}_i/g_{\text{leak}}$	$V_{1/2}$ [mV]	$s$ [mV]	$V_{1/2}$ [mV]	$s$ [mV]
8.452	-78.2	3.6	-40.4	-9.7
9.791	-76.3	3.1	-50.4	-5.5
2.498	-33.7	1283.7	-15.1	-8.0

  

 

1998-08-16