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Currently my focus is on modeling the contribution of
various noise sources to the
observed subthreshold voltage fluctuations in single neurons. The most significant sources are
random spontaneous release from synaptic connections, and the stochastic opening and closing of
ion channels in the neuron's membrane. Individual ion channels, which are central to signal
initiation and propagation in neurons, open and close probablistically (and hence randomly), thereby
permitting current flow, which leads to voltage fluctuations in the neuron's membrane.
Starting with a model of ion channel kinetics, and using the theory of Markov chains, we can
calculate the power spectrum of these current fluctuations. Furthermore, using cable theory
and the NEURON simulation environment, its possible to
calculate the resulting power spectrum of the voltage fluctuations that occur at the cell body and
compare these with experimental calculations.
Below is a picture of me in Rio
de Janeiro (I am the one on the right). Other times I look like
this .
For my non-academic interests click
HERE .
This site has been visited
times since September 10th, 2002.